T1. Delta Air Lines
11/11
Photo: Delta Air Lines Boeing 757-200 taking off from LAX. (photo via Laser1987/iStock Editorial/Getty Images Plus)
Delta Air Lines is the safest of the Big Four U.S. airlines, according to the Safe Travel Barometer, earning a 4.4 out of 5. In addition to blocking middle seats, Delta has partnered with organizations like the Mayo Clinic and RB (makers of Lysol) and is looking into how ATP testing devices that are used to swab surfaces in hospitals and restaurants could be incorporated into its cleaning program.