50 Great Destinations for a Long Weekend

So it’s a holiday weekend or, even better, the boss gave everybody Friday off.

Now what?

In the immortal words of the boys from Animal House—“Road Trip!”

Whether you fly or drive, a long weekend away can be quite the elixir. From the obvious, such as big cities like New York and San Francisco, to the off-the-beaten-path, like time in the mountains in Asheville, N.C., here are 50 great destinations to get away to, in no particular order.