Chattanooga, Tennessee
37/51As far as city settings go, they don't come much prettier than 'Nooga's. Tucked beside the Tennessee River under a range of mountains, you could fill a weekend here simply strolling up and down the Tennessee Riverwalk, making runs to the bevy of excellent local coffee, breakfast and biscuit purveyors. In addition, it would be rude to come all this way and not take a river cruise, visit the Tennessee Aquarium or do some hiking.