1. Alaska Airlines
12/12Alaska Airlines is the best domestic airline in 2021, based on WalletHub's comprehensive research. The carrier earned an overall score of 56.54 and was also the safest in 2020, earning a safety score of 20.55. The category takes into consideration average fleet age, face mask availability, blocked middle seat policy and the number of accidents, among other factors. Alaska also tied SkyWest and Envoy as the most pet-friendly.